Lois Griffin

Lois Griffin is one of the main characters from the animated (adult) sitcom series Family Guy.

Peter, Peter Caviar Eater
In Season 2, Episode 1 entitled “Peter, Peter Caviar Eater“, Lois is seen sitting in a chair and her left shoe is removed when getting a foot massage.

A video of the action can be seen here: https://www.youtube.com/watch?v=ZvS1xTfRlNI&t=5m33s.

No Bones About It
Near then end the first segment of "Family Guy Viewer Mail No. 1" Lois is seen with only one shoe when it was revealed that she, along with the others gave part of their bones to Peter as an experiment, for her it was right leg, her neck, and left arm.

Bill and Peter's Bogus Journey
In the third scene of Season 5, Episode 13 entitled “Bill and Peter's Bogus Journey”, Lois is seen wearing only one shoe while cleaning her right shoe.

A video of the action can be seen here: https://www.youtube.com/watch?v=DfuHl8R_6eI&t=2m38s.

Lottery Fever
Towards the end of Season 10 Episode 1 entitled “Lottery Fever”, Lois's right shoe is missing and she is seen sitting on the sidewalk wearing one shoe.

A video of the action can be seen here: https://www.youtube.com/watch?v=3X1AVkx7W1w&t=20m08s.

Grimm Job
In Season 12, Episode 10 entitled “Grimm Job”, Lois loses her glass slipper during the Cinderella segment of the episode.

A video of the action can be seen here: https://www.youtube.com/watch?v=lnlFxUqRYVA&t=2m12s.

Peter's Lost Youth
In Season 15, Episode 17 entitled “Peter’s Lost Youth”, Lois is seen sitting on a cart wearing only one shoe due to an injured leg while wearing a baseball uniform. Then she is seen wearing one shoe when her right foot is wearing a cast.

All About Alana
In the climax of Season 20, Episode 17 entitled "All About Alana" Lois is seen with one shoe after she fell into a glass window at a church.